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Gap Junctions: Two neuron exampleΒΆ
Run this example as a Jupyter notebook:
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This script simulates two Hodgkin-Huxley neurons of type hh_psc_alpha_gap
connected by a gap junction. Both neurons receive a constant current of
100.0 pA. The neurons are initialized with different membrane potentials and
synchronize over time due to the gap-junction connection.
import matplotlib.pyplot as plt
import nest
import numpy
nest.ResetKernel()
First we set the resolution of the simulation, create two neurons and
create a voltmeter
for recording.
nest.resolution = 0.05
neuron = nest.Create("hh_psc_alpha_gap", 2)
vm = nest.Create("voltmeter", params={"interval": 0.1})
Then we set the constant current input, modify the inital membrane
potential of one of the neurons and connect the neurons to the voltmeter
.
neuron.I_e = 100.0
neuron[0].V_m = -10.0
nest.Connect(vm, neuron, "all_to_all")
In order to create the gap_junction
connection we employ the
all_to_all
connection rule: Gap junctions are bidirectional connections,
therefore we need to connect neuron[0] to neuron[1] and neuron[1] to
neuron[0]:
nest.Connect(
neuron, neuron, {"rule": "all_to_all", "allow_autapses": False}, {"synapse_model": "gap_junction", "weight": 0.5}
)
Finally we start the simulation and plot the membrane potentials of both neurons.
nest.Simulate(351.0)
senders = vm.events["senders"]
times = vm.events["times"]
v_m_values = vm.events["V_m"]
plt.figure(1)
plt.plot(times[numpy.where(senders == 1)], v_m_values[numpy.where(senders == 1)], "r-")
plt.plot(times[numpy.where(senders == 2)], v_m_values[numpy.where(senders == 2)], "g-")
plt.xlabel("time (ms)")
plt.ylabel("membrane potential (mV)")
plt.show()
Total running time of the script: ( 0 minutes 0.000 seconds)