hh_psc_alpha_gap – Hodgkin-Huxley neuron model with gap-junction support ======================================================================== Description +++++++++++ ``hh_psc_alpha_gap`` is an implementation of a spiking neuron using the Hodgkin-Huxley formalism. In contrast to ``hh_psc_alpha`` the implementation additionally supports gap junctions. 1. Postsynaptic currents Incoming spike events induce a postsynaptic change of current modelled by an alpha function. The alpha function is normalized such that an event of weight 1.0 results in a peak current of 1 pA. 2. Spike Detection Spike detection is done by a combined threshold-and-local-maximum search: if there is a local maximum above a certain threshold of the membrane potential, it is considered a spike. 3. Gap Junctions Gap Junctions are implemented by a gap current of the form :math:`g_{ij}( V_i - V_j)`. See also [1]_, [2]_, [3]_, [4]_. Parameters ++++++++++ The following parameters can be set in the status dictionary. =========== ====== ============================================================ tau_ex ms Rise time of the excitatory synaptic alpha function tau_in ms Rise time of the inhibitory synaptic alpha function g_K nS Potassium peak conductance V_m mV Membrane potential E_L mV Leak reversal potential g_L nS Leak conductance C_m pF Capacity of the membrane tau_syn_ex ms Rise time of the excitatory synaptic alpha function tau_syn_in ms Rise time of the inhibitory synaptic alpha function E_Na mV Sodium reversal potential g_Na nS Sodium peak conductance E_K mV Potassium reversal potential g_Kv1 nS Potassium peak conductance g_Kv3 nS Potassium peak conductance Act_m real Activation variable m Inact_h real Inactivation variable h Act_n real Activation variable n I_e pA External input current =========== ====== ============================================================ References ++++++++++ .. [1] Gerstner W, Kistler W. Spiking neuron models: Single neurons, populations, plasticity. Cambridge University Press .. [2] Mancilla JG, Lewis TG, Pinto DJ, Rinzel J, Connors BW (2007). Synchronization of electrically coupled pairs of inhibitory interneurons in neocortex, Journal of Neurosciece, 27:2058-2073 DOI: https://doi.org/10.1523/JNEUROSCI.2715-06.2007 (parameters taken from here) .. [3] Hodgkin AL and Huxley A F (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology 117. DOI: https://doi.org/10.1113/jphysiol.1952.sp004764 .. [4] Hahne J, Helias M, Kunkel S, Igarashi J, Bolten M, Frommer A, Diesmann M (2015). A unified framework for spiking and gap-junction interactions in distributed neuronal netowrk simulations. Frontiers in Neuroinformatics, 9:22. DOI: https://doi.org/10.3389/fninf.2015.00022 Sends +++++ SpikeEvent, GapJunctionEvent Receives ++++++++ SpikeEvent, GapJunctionEvent, CurrentEvent, DataLoggingRequest See also ++++++++ :doc:`Neuron `, :doc:`Current-Based `, :doc:`Hodgkin-Huxley `, :doc:`Gap Junction `